Price: £100.00
Scion Publishing Ltd
2007
Hardback - 450pp
ISBN 9781904842279
Clare Sansom; Ofer Markman
Description
This glycobiology book is truly unique. Produced to commemorate the 80th birthday of Nathan Sharon, Glycobiology is an essential reference tool for anyone working in the field. Most research review volumes are narrowly focused. This book is different. It is a state-of-the-art fully comprehensive review volume covering a deliberately wide spectrum of work in this important field. With 28 chapters, covering over 350 pages, this title describes the latest research findings - from chemistry to biology and from pure science to industrial and medical applications.
The book is written by world-class researchers and brings the reader fully up-to-date with the latest advances and forward thinking. All the major areas of glycobiology are covered including the synthesis of carbohydrates and glycoconjugates, their structural and functional analysis, carbohydrate binding proteins, carbohydrate modifying enzymes, and the applications of glycobiology research in medicine and industry. All active researchers in the glycosciences will value access to this important research compendium whether it be in the local library or in the lab.
Contents
SECTION 1. Introduction
1. Half a century at the carbohydrate-protein interface Clare Sansom,
3. Sugar-lectin interactions: glycotargeting with synthetic glycoconjugates Michel Monsigny et al.,
4. Recent developments in the synthesis and application of sialylmimetics Hansjörg Streicher and Heike Busse,
5. Structure and function of the chondroitin/dermatan sulfates Robert Lauder,
SECTION 4. Cell Biology of Carbohydrates and Glycoproteins
9. Some observations on the biology of cell surface heparan sulfate proteoglycans John Gallagher,
11. Intracellular lectin involvement in glycoprotein maturation and quality control in the secretory pathway Gerardo Lederkremer,
12. The diversity of sialic acids and their interplay with lectins Roland Schauer, Biochemisches Institut
14. Proteinglycan interactions in immunoregulation: galectins as tuners of the inflammatory response Gabriel Rabinovich,
15. Recognition of bacterial glycoepitopes by pulmonary C-type lectins as an arm of lung innate immunity Itzhak Ofek,
SECTION 6. Carbohydrate-Modifying Enzymes
17. Complex carbohydrate-modifying enzymes Spencer Williams,
20. Glycobiology of mucins in the human gastrointestinal tract Anthony Corfield, Mucin Research Group,
24. Pathogenhost interactions in Entamoeba histolytica David Mirelman, Weizmann Institute of Science
SECTION 8. Industrial Glycobiology
25. The development of iminosugars as drugs Bryan Winchester,
28. Lectin chips and CarboDeep: a rapid carbohydrate fingerprinting technology and its application for the food scientists Ofer Markman, Nutricognia
Afterword Nathan Sharon